Partition effect of polyethylene glycol in partition thin-layer chromatography

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Quantification of Polyethylene Glycol Esters of Methotrexate and Determination of Their Partition Coefficients by Validated HPLC Methods

Conjugation of methotrexate (MTX) (MW 454) with different molecular weights of polyethylene glycol (PEG) including methoxy-peg (mpeg) 750 D and 5000 D and diol-peg 35000 D led to compounds that are physicochemically highly different from the parent compound, MTX. In this study, an HPLC system consisting of C8 column and UV detector (?=342 nm), using a mixture of 30:70 v/v phosphate-citrate buff...

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Quantification of Polyethylene Glycol Esters of Methotrexate and Determination of Their Partition Coefficients by Validated HPLC Methods

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quantification of polyethylene glycol esters of methotrexate and determination of their partition coefficients by validated hplc methods

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ژورنال

عنوان ژورنال: BUNSEKI KAGAKU

سال: 1973

ISSN: 0525-1931

DOI: 10.2116/bunsekikagaku.22.306